USA
Analytical Standards
Controlled Research Environment
Research Product
MOTS-c
1. Product Overview
MOTS-c is a mitochondrial-derived peptide that has attracted significant scientific interest in research involving cellular energy regulation, metabolic signaling, mitochondrial function, and adaptive stress response pathways. Ongoing studies continue to explore its interaction with metabolic processes, cellular homeostasis, and mitochondrial communication mechanisms. MOTS-c is supplied as a lyophilized research peptide and undergoes analytical testing to verify identity, purity, and consistency.
Manufactured in a controlled research environment, this product is intended exclusively for laboratory and scientific research applications.
2. Specifications
| Product Name | MOTS-c | Testing Method | HPLC |
|---|---|---|---|
| Synonym | Mitochondrial Open Reading Frame of the 12S rRNA-c | Storage Condition | 2–8°C |
| Format | Lyophilized Powder | Shelf Life | 24 Months |
| Content | 5mg per vial | Manufacturing Standard | GMP Standard Research Environment |
| Purity | 99% HPLC | Country of Origin | USA |
| Appearance | White to Off White Lyophilized Powder | Intended Use | Research Use Only |
3. Research Summary
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region and has attracted significant scientific interest in studies involving cellular energy regulation, metabolic signaling, mitochondrial function, adaptive stress responses, and cellular homeostasis. Research has explored its interaction with pathways associated with energy utilization, metabolic adaptation, and mitochondrial-to-nuclear communication.
Preclinical investigations have examined the role of MOTS-c in metabolic regulation, exercise physiology, glucose metabolism, and cellular stress response mechanisms. Ongoing laboratory studies continue to evaluate its involvement in mitochondrial signaling networks and broader metabolic research applications.
4. Scientific References
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-454.
- Kim KH, Son JM, Benayoun BA, Lee C. The mitochondrial encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism. 2018;28(4):516-524.
- Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021;12:470.
- Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating metabolism and stress adaptation. Free Radical Biology and Medicine. 2016;100:182-187.
- Yen K, Lee C, Mehta H, Cohen P. The emerging role of mitochondrial-derived peptides in metabolic regulation and aging research. Journal of Clinical Investigation. 2013;123(4):1607-1611.
Disclaimer: This product is intended strictly for research use only. It is not intended for human consumption, clinical application, diagnostic procedures, therapeutic use, veterinary use, or household use. The information provided is for scientific and educational reference purposes only and should not be interpreted as medical advice, treatment guidance, or usage instructions. This product should be handled only by qualified professionals trained in laboratory practices. Purchasers and end users are solely responsible for ensuring compliance with all applicable laws, regulations, and institutional requirements governing the purchase, storage, handling, and use of research materials.
